The average bus between Des Moines and Harrisburg takes 31h 53m and the fastest bus takes 25h 50m. The bus service runs several times per day from Des Moines to Harrisburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Des Moines and Harrisburg. The earliest departure is at 9:20 AM in the morning, and the last departure from Des Moines is at 9:45 AM which arrives into Harrisburg at 1:55 AM. All services require a transfer, and take on average 31h 53m. The schedules shown below are for the next available departures.
Arrives next day

26h 50m • 1 change
Arrives +2 days

40h 10m • 1 change
Arrives next day

26h 50m • 1 change
Arrives +2 days

40h 10m • 1 change
Arrives next day

26h 50m • 1 change
Arrives +2 days

40h 10m • 1 change
Want to know about travelling from Des Moines to Harrisburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Des Moines to Harrisburg. However, there are services departing from Des Moines station and arriving at Harrisburg station via Chicago Bus Station station. The journey, including transfers, takes approximately 31h 53m.
Des Moines to Harrisburg bus services, operated by Greyhound USA, depart from Des Moines station.
Des Moines to Harrisburg bus services, operated by Greyhound USA, arrive at Harrisburg Bus Station.
Book your Des Moines to Harrisburg bus tickets online with Greyhound USA and Flixbus USA.
The distance between Des Moines and Harrisburg is 1,410.4 km. The road distance is 1,779 km.
You can take a bus from Des Moines to Harrisburg Bus Station via Chicago Bus Station in around 24h.