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Des Moines to Harrisburg, Pa buses

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Trip Overview

The average bus between Des Moines and Harrisburg, Pa takes 31h 36m and the fastest bus takes 25h 50m. There is at least one bus per day from Des Moines to Harrisburg, Pa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

31h 36m
Duration
1,112 mi
Distance
$223
Average price
Once daily
Frequency

Des Moines to Harrisburg, Pa bus times

Buses run once daily between Des Moines and Harrisburg, Pa. The earliest departure is at 9:20 AM in the morning, and the last departure from Des Moines is at 9:45 AM which arrives into Harrisburg, Pa at 1:35 AM. All services require a transfer, and take on average 31h 36m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA25h 50m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA25h 50m • 1 change
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USA38h 50m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA25h 50m • 1 change
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USA38h 50m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA25h 50m • 1 change
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USA38h 50m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA25h 50m • 1 change
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USA38h 50m • 1 change

Frequently asked questions

Want to know about travelling from Des Moines to Harrisburg, Pa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Harrisburg, Pa.ExpandLaunch map view
  • Distance: 1,111.6 mi
  • Duration: 31h 36m

What companies run services between Des Moines, IA, USA and Harrisburg, Pa, PA, USA?

You can take a bus from Des Moines to Harrisburg Bus Station via Chicago Bus Station in around 24h.

Operators