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Des Moines to Harrisburg, Pa buses

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Trip Overview

The bus between Des Moines and Harrisburg, Pa takes 25h 35m. The bus runs, on average, 6 times per week from Des Moines to Harrisburg, Pa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

25h 35m
Duration
1,023 mi
Distance
$220
Average price
6 times a week
Frequency

Des Moines to Harrisburg, Pa bus times

Buses run 6 times a week between Des Moines and Harrisburg, Pa. The service departs Des Moines at 7:50 AM in the morning, which arrives into Harrisburg, Pa at 10:25:00. All services require a transfer, and take on average 25h 35m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 35m • 1 change

Departing Sunday, November 8, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 35m • 1 change

Departing Monday, November 9, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 35m • 1 change

Departing Tuesday, November 10, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 35m • 1 change

Departing Wednesday, November 11, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 35m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAGreyhound USA25h 35m • 1 change

Frequently asked questions

Want to know about travelling from Des Moines to Harrisburg, Pa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Harrisburg, Pa.ExpandLaunch map view
  • Distance: 1,023.4 mi
  • Duration: 25h 35m

What companies run services between Des Moines, IA, USA and Harrisburg, Pa, PA, USA?

You can take a bus from Des Moines to Harrisburg Bus Station via Indianapolis Union Station in around 24h 25m.

Operators