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Des Moines to Mechanicsburg buses

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Trip Overview

The average bus between Des Moines and Mechanicsburg takes 29h 41m and the fastest bus takes 26h 17m. The bus runs, on average, 6 times per week from Des Moines to Mechanicsburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

29h 41m
Duration
1,032 mi
Distance
$223
Average price
6 times a week
Frequency

Des Moines to Mechanicsburg bus times

Buses run 6 times a week between Des Moines and Mechanicsburg. The service departs Des Moines at 7:50 AM in the morning, which arrives into Mechanicsburg at 11:07:02. All services require a transfer at Indianapolis Union Station and take an average of 29h 41m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USARabbit Transit26h 17m • 2 changes

Departing Friday, November 6, 2026

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    Arrives next day

    Greyhound USAGreyhound USARabbit Transit27h 51m • 2 changes

Departing Saturday, November 7, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USARabbit Transit45h 8m • 2 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    Greyhound USAGreyhound USARabbit Transit26h 17m • 2 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USARabbit Transit26h 17m • 2 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USARabbit Transit26h 17m • 2 changes

Frequently asked questions

Want to know about travelling from Des Moines to Mechanicsburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Mechanicsburg.ExpandLaunch map view
  • Distance: 1,032.4 mi
  • Duration: 29h 41m

What companies run services between Des Moines, IA, USA and Mechanicsburg, Cumberland County, PA, USA?

You can take a bus from Des Moines to E Main St & Arch St WB via Indianapolis Union Station, Harrisburg Bus Station, and Market Square Transfer Center in around 25h 29m.

Operators