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Des Moines to New Orleans buses

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Trip Overview

The average bus between Des Moines and New Orleans takes 40h 47m and the fastest bus takes 38h 30m. The bus runs, on average, 6 times per week from Des Moines to New Orleans. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

40h 47m
Duration
1,146 mi
Distance
$263
Average price
6 times a week
Frequency

Des Moines to New Orleans bus times

Buses run 6 times a week between Des Moines and New Orleans. The earliest departure is at 4:20 AM at night, and the last departure from Des Moines is at 11:45 PM which arrives into New Orleans at 5:50 PM. All services require a transfer at Kansas City and take an average of 40h 47m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAGreyhound USA38h 30m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Jefferson LinesGreyhound USAGreyhound USA38h 30m • 2 changes
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    Arrives +2 days

    Jefferson LinesGreyhound USAGreyhound USA43h 5m • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USAGreyhound USA43h 5m • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesGreyhound USAGreyhound USA43h 5m • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Jefferson LinesGreyhound USAGreyhound USA38h 30m • 2 changes

Frequently asked questions

Want to know about travelling from Des Moines to New Orleans? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to New Orleans.ExpandLaunch map view
  • Distance: 1,146 mi
  • Duration: 40h 47m

What companies run services between Des Moines, IA, USA and New Orleans, LA, USA?

You can take a bus from Des Moines to New Orleans Bus Station via Kansas City, Kansas City Bus Station, and St Louis Bus Station in around 26h 20m.

Operators