The average bus between Des Moines and Plymouth takes 43h and the fastest bus takes 36h 20m. There is at least one bus per day from Des Moines to Plymouth. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Des Moines and Plymouth. The earliest departure is at 9:20 AM in the morning, and the last departure from Des Moines is at 9:45 AM which arrives into Plymouth at 12:20 PM. All services require a transfer at Chicago Bus Station and take an average of 43h. The schedules shown below are for the next available departures.
Arrives next day



37h 20m • 3 changes
Arrives +2 days



2d 2h • 3 changes
Arrives next day



37h 20m • 3 changes
Arrives +2 days



2d 2h • 3 changes
Want to know about travelling from Des Moines to Plymouth? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Des Moines to Plymouth. However, there are services departing from Des Moines station and arriving at Plymouth station via Chicago Bus Station station. The journey, including transfers, takes approximately 43h.
Des Moines to Plymouth bus services, operated by Greyhound USA, depart from Des Moines station.
Des Moines to Plymouth bus services, operated by Greyhound USA, arrive at Park & Ride Lot, Ex 13 Info. Ctr. station.
The distance between Des Moines and Plymouth is 1,897 km. The road distance is 2,376 km.
You can take a bus from Des Moines to Park & Ride Lot, Ex 13 Info. Ctr. via Chicago Bus Station, New York Midtown, Boston, and Boston South Buses in around 31h 34m.