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Des Moines to Portland buses

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Trip Overview

The average bus between Des Moines and Portland takes 44h 5m and the fastest bus takes 37h 50m. There is at least one bus per day from Des Moines to Portland. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

44h 5m
Duration
1,640 mi
Distance
$330
Average price
Once daily
Frequency

Des Moines to Portland bus times

Buses run once daily between Des Moines and Portland. The earliest departure is at 9:20 AM in the morning, and the last departure from Des Moines is at 9:45 AM which arrives into Portland at 2:10 PM. All services require a transfer at Chicago Bus Station and take an average of 44h 5m. The schedules shown below are for the next available departures.

Departing Wednesday, November 4, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAConcord Coach Lines37h 50m • 3 changes

Departing Thursday, November 5, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAConcord Coach Lines37h 50m • 3 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAConcord Coach Lines2d 3h • 3 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAConcord Coach Lines37h 50m • 3 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAConcord Coach Lines2d 3h • 3 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAConcord Coach Lines37h 50m • 3 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAConcord Coach Lines2d 3h • 3 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAConcord Coach Lines37h 50m • 3 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAFlixbus USAConcord Coach Lines2d 5h • 3 changes

Frequently asked questions

Want to know about travelling from Des Moines to Portland? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Portland.ExpandLaunch map view
  • Distance: 1,640.3 mi
  • Duration: 44h 5m

What companies run services between Des Moines, IA, USA and Portland, ME, USA?

You can take a bus from Des Moines to Portland, ME via Chicago Bus Station, New York Midtown, Boston, and Boston, MA - South Station in around 35h 43m.

Operators