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Des Moines to San Antonio buses

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Trip Overview

The average bus between Des Moines and San Antonio takes 47h and the fastest bus takes 44h 15m. The bus runs, on average, 5 times per week from Des Moines to San Antonio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

47h
Duration
1,052 mi
Distance
$223
Average price
5 times a week
Frequency

Des Moines to San Antonio bus times

Buses run 5 times a week between Des Moines and San Antonio. The earliest departure is at 4:20 AM at night, and the last departure from Des Moines is at 11:45 PM which arrives into San Antonio at 11:35 PM. All services require a transfer at Kansas City and take an average of 47h. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

  •  → 

    Arrives next day

    Jefferson LinesFlixbus USAFlixbus USA44h 15m • 2 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives next day

    Jefferson LinesFlixbus USAFlixbus USA44h 15m • 2 changes
  •  → 

    Arrives +2 days

    Jefferson LinesFlixbus USAFlixbus USA2d • 2 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesFlixbus USAFlixbus USA2d • 2 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives +2 days

    Jefferson LinesFlixbus USAFlixbus USA2d • 2 changes

Frequently asked questions

Want to know about travelling from Des Moines to San Antonio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to San Antonio.ExpandLaunch map view
  • Distance: 1,051.7 mi
  • Duration: 47h

What companies run services between Des Moines, IA, USA and San Antonio, TX, USA?

You can take a bus from Des Moines to San Antonio Bus Station via Kansas City, Kansas City Bus Station, and Denton in around 22h 20m.

Operators