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Des Moines to San Francisco buses

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Trip Overview

The bus between Des Moines and San Francisco takes 43h 20m. The bus runs, on average, 6 times per week from Des Moines to San Francisco. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

43h 20m
Duration
1,968 mi
Distance
$415
Average price
6 times a week
Frequency

Des Moines to San Francisco bus times

Buses run 6 times a week between Des Moines and San Francisco. The service departs Des Moines at 7:35 PM in the evening, which arrives into San Francisco at 12:55:00. All services require a transfer at Denver Union Station and take an average of 43h 20m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA43h 20m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA43h 20m • 2 changes

Departing Friday, November 13, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA43h 20m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA43h 20m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA43h 20m • 2 changes

Departing Monday, November 16, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA43h 20m • 2 changes

Frequently asked questions

Want to know about travelling from Des Moines to San Francisco? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to San Francisco.ExpandLaunch map view
  • Distance: 1,967.7 mi
  • Duration: 43h 20m

What companies run services between Des Moines, IA, USA and San Francisco, CA, USA?

You can take a bus from Des Moines to San Francisco Bus Station via Denver Union Station and Sparks Transit Center in around 43h 30m.

Operators