The average bus between Des Moines and St. Louis takes 9h 29m and the fastest bus takes 9h 25m. There is at least one bus per day from Des Moines to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Des Moines and St. Louis. The earliest departure is at 4:20 AM at night, and the last departure from Des Moines is at 11:45 PM which arrives into St. Louis at 8:10 AM. All services require a transfer at Kansas City and take an average of 9h 29m. The schedules shown below are for the next available departures.
Want to know about travelling from Des Moines to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Des Moines to St. Louis. However, there are services departing from Des Moines station and arriving at St. Louis station via Kansas City. The journey, including transfers, takes approximately 9h 29m.
Des Moines to St. Louis bus services, operated by Jefferson Lines, depart from Des Moines station.
Des Moines to St. Louis bus services, operated by Jefferson Lines, arrive at St Louis Bus Station.
Book your Des Moines to St. Louis bus tickets online with Jefferson Lines and Greyhound USA.
The distance between Des Moines and St. Louis is 439.8 km. The road distance is 710 km.
You can take a bus from Des Moines to St Louis Bus Station via Kansas City and Kansas City Bus Station in around 8h 30m.
