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Des Moines to Tallahassee buses

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Trip Overview

The bus between Des Moines and Tallahassee takes 35h 25m. The bus runs, on average, 6 times per week from Des Moines to Tallahassee. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

35h 25m
Duration
1,232 mi
Distance
$256
Average price
6 times a week
Frequency

Des Moines to Tallahassee bus times

Buses run 6 times a week between Des Moines and Tallahassee. The service departs Des Moines at 7:50 AM in the morning, which arrives into Tallahassee at 20:15:00. All services require a transfer at Indianapolis Union Station and take an average of 35h 25m. The schedules shown below are for the next available departures.

Departing Wednesday, November 4, 2026

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    Arrives next day

    Greyhound USAAmtrak ThruwayGreyhound USA35h 25m • 2 changes

Departing Thursday, November 5, 2026

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    Arrives next day

    Greyhound USAAmtrak ThruwayGreyhound USA35h 25m • 2 changes

Departing Friday, November 6, 2026

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    Arrives next day

    Greyhound USAAmtrak ThruwayGreyhound USA35h 25m • 2 changes

Departing Saturday, November 7, 2026

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    Arrives next day

    Greyhound USAAmtrak ThruwayGreyhound USA35h 25m • 2 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    Greyhound USAAmtrak ThruwayGreyhound USA35h 25m • 2 changes

Departing Monday, November 9, 2026

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    Arrives next day

    Greyhound USAAmtrak ThruwayGreyhound USA35h 25m • 2 changes

Frequently asked questions

Want to know about travelling from Des Moines to Tallahassee? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Tallahassee.ExpandLaunch map view
  • Distance: 1,231.7 mi
  • Duration: 35h 25m

What companies run services between Des Moines, IA, USA and Tallahassee, FL, USA?

You can take a bus from Des Moines to Tallahassee via Indianapolis Union Station and Nashville Bus Station in around 25h 55m.

Operators