The average bus between Des Moines and Worcester takes 38h 50m and the fastest bus takes 36h 25m. There is at least one bus per day from Des Moines to Worcester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Des Moines and Worcester. The earliest departure is at 8:15 AM in the morning, and the last departure from Des Moines is at 11:15 PM which arrives into Worcester at 4:30 PM. All services require a transfer at Chicago Bus Station and take an average of 38h 50m. The schedules shown below are for the next available departures.
Arrives next day


36h 25m • 2 changes
Arrives +2 days


41h 15m • 2 changes
Arrives next day


36h 25m • 2 changes
Arrives +2 days


41h 15m • 2 changes
Arrives next day


36h 25m • 2 changes
Arrives +2 days


41h 15m • 2 changes
Want to know about travelling from Des Moines to Worcester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Des Moines to Worcester. However, there are services departing from Des Moines station and arriving at Worcester station via Chicago. The journey, including transfers, takes approximately 38h 50m.
Des Moines to Worcester bus services, operated by Burlington Trailways, depart from Des Moines station.
Des Moines to Worcester bus services, operated by Burlington Trailways, arrive at Worcester Union Station.
Book your Des Moines to Worcester bus tickets online with Burlington Trailways, Flixbus USA and Greyhound USA.
The distance between Des Moines and Worcester is 1,800.5 km. The road distance is 2,264 km.
You can take a bus from Des Moines to Worcester Union Station via Chicago Bus Station and Newark Penn Station in around 28h 15m.