The average bus between Downingtown and Penn Medicine Station takes 2h 26m and the fastest bus takes 1h 52m. There is a bus service every few hours from Downingtown to Penn Medicine Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Downingtown and Penn Medicine Station. The earliest departure is at 6:03 AM in the morning, and the last departure from Downingtown is at 8:54 PM which arrives into Penn Medicine Station at 11:37 PM. All services require a transfer at West Chester Transit Center and take an average of 2h 26m. The schedules shown below are for the next available departures.


2h 15m • 2 changes


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2h 3m • 2 changes


2h 33m • 2 changes


2h 20m • 2 changes


2h 20m • 2 changes


2h 3m • 2 changes


2h 33m • 2 changes


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2h 20m • 2 changes
Want to know about travelling from Downingtown to Penn Medicine Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Downingtown to Penn Medicine Station. However, there are services departing from Downingtown station and arriving at Penn Medicine Station station via West Chester Transit Center. The journey, including transfers, takes approximately 2h 26m.
Downingtown to Penn Medicine Station bus services, operated by SEPTA, depart from Lancaster Av & Green St - MBNS station.
Downingtown to Penn Medicine Station bus services, operated by SEPTA, arrive at 69th St Transit Center station.
The distance between Downingtown and Penn Medicine Station is 44.2 km. The road distance is 68 km.
You can take a bus from Lancaster Av & Green St - MBNS to Penn Medicine Station via West Chester Transit Center, 69th St Transit Center, 69th St Transit Center South Terminal, and Chestnut St & 36th St in around 2h 34m.