The average bus between Downtown Eastside and San Francisco takes 26h 35m and the fastest bus takes 24h 20m. The bus service runs several times per day from Downtown Eastside to San Francisco. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Downtown Eastside and San Francisco. The earliest departure is at 9:00 AM in the morning, and the last departure from Downtown Eastside is at 4:55 PM which arrives into San Francisco at 5:15 PM. All services require a transfer at Seattle Bus Station and take an average of 26h 35m. The schedules shown below are for the next available departures.
Arrives next day


27h 35m • 2 changes
Arrives next day


24h 20m • 2 changes
Arrives next day


27h 35m • 2 changes
Arrives next day


24h 20m • 2 changes
Arrives next day


27h 35m • 2 changes
Arrives next day


24h 20m • 2 changes
Arrives next day


27h 35m • 2 changes
Arrives next day


24h 20m • 2 changes
Want to know about travelling from Downtown Eastside to San Francisco? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Downtown Eastside to San Francisco. However, there are services departing from Downtown Eastside station and arriving at San Francisco station via Seattle Bus Station station. The journey, including transfers, takes approximately 26h 35m.
Downtown Eastside to San Francisco bus services, operated by Flixbus USA, depart from Vancouver station.
Downtown Eastside to San Francisco bus services, operated by Flixbus USA, arrive at San Francisco Bus Station.
Book your Downtown Eastside to San Francisco bus tickets online with Flixbus USA and Greyhound USA.
The distance between Downtown Eastside and San Francisco is 1,280.6 km. The road distance is 1,609 km.
You can take a bus from Vancouver to San Francisco Bus Station via Seattle Bus Station and Sacramento Bus Station in around 26h.