The average bus between Duke University and Winston-Salem takes 4h 4m and the fastest bus takes 1h 58m. The bus service runs several times per day from Duke University to Winston-Salem. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Duke University and Winston-Salem. The earliest departure is at 1:40 PM in the afternoon, and the last departure from Duke University is at 11:40 PM which arrives into Winston-Salem at 6:45 AM. All services require a transfer at Flowers Dr at Duke Gardens and take an average of 4h 4m. The schedules shown below are for the next available departures.

2h 44m • 1 change

1h 59m • 1 change
Arrives next day

7h 4m • 1 change

2h 44m • 1 change

1h 59m • 1 change
Arrives next day

7h 4m • 1 change

2h 44m • 1 change

1h 59m • 1 change
Arrives next day

7h 4m • 1 change

2h 44m • 1 change

1h 59m • 1 change
Arrives next day

7h 4m • 1 change
Want to know about travelling from Duke University to Winston-Salem? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Duke University to Winston-Salem. However, there are services departing from Duke University station and arriving at Winston-Salem station via Winston Salem(Trans Center). The journey, including transfers, takes approximately 4h 4m.
Duke University to Winston-Salem bus services, operated by GoDurham, depart from Durham station.
Duke University to Winston-Salem bus services, operated by GoDurham, arrive at Winston Salem(Trans Center) station.
The distance between Duke University and Winston-Salem is 117.8 km. The road distance is 132 km.
Greyhound USA operates a bus from Durham to Winston Salem(Trans Center) 3 times a day. Tickets cost $12–24 and the journey takes 1h 35m.