The average bus between East Boston and Hyannis takes 2h 2m and the fastest bus takes 1h 54m. There is at least one bus per day from East Boston to Hyannis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between East Boston and Hyannis. The earliest departure is at 11:36 AM in the morning, and the last departure from East Boston is at 7:31 PM which arrives into Hyannis at 9:35 PM. All services require a transfer at South Station and take an average of 2h 2m. The schedules shown below are for the next available departures.

1h 54m • 1 change

1h 57m • 1 change

2h 12m • 1 change

2h 10m • 1 change
Want to know about travelling from East Boston to Hyannis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from East Boston to Hyannis. However, there are services departing from East Boston station and arriving at Hyannis station via Hyannis Transportation Center. The journey, including transfers, takes approximately 2h 2m.
East Boston to Hyannis bus services, operated by MBTA, depart from Boston South Station.
East Boston to Hyannis bus services, operated by MBTA, arrive at Hyannis Transportation Center station.
The distance between East Boston and Hyannis is 101.7 km. The road distance is 123 km.
Peter Pan Bus Lines operates a bus from Boston South Station to Hyannis Transportation Center every 3 hours. Tickets cost $15–40 and the journey takes 1h 35m.