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Effingham to Louisville buses

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Trip Overview

The average bus between Effingham and Louisville takes 6h 8m and the fastest bus takes 4h 50m. The bus service runs several times per day from Effingham to Louisville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 8m
Duration
258 mi
Distance
$53
Average price
Twice daily
Frequency

Effingham to Louisville bus times

Buses run twice daily between Effingham and Louisville. The earliest departure is at 10:50 AM in the morning, and the last departure from Effingham is at 4:05 PM which arrives into Louisville at 6:55 AM. All services require a transfer, and take on average 6h 8m. The schedules shown below are for the next available departures.

Departing Saturday, October 10, 2026

  •  → 

    Greyhound USAAmtrak Thruway6h 10m • 1 change
  •  → 

    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Sunday, October 11, 2026

  •  → 

    Greyhound USAAmtrak Thruway6h 10m • 1 change
  •  → 

    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Monday, October 12, 2026

  •  → 

    Greyhound USAAmtrak Thruway6h 10m • 1 change
  •  → 

    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Tuesday, October 13, 2026

  •  → 

    Greyhound USAAmtrak Thruway6h 10m • 1 change
  •  → 

    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Wednesday, October 14, 2026

  •  → 

    Greyhound USAAmtrak Thruway6h 10m • 1 change
  •  → 

    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Thursday, October 15, 2026

  •  → 

    Greyhound USAAmtrak Thruway6h 10m • 1 change
  •  → 

    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Friday, October 16, 2026

  •  → 

    Greyhound USAAmtrak Thruway6h 10m • 1 change
  •  → 

    Arrives next day

    Greyhound USAAmtrak Thruway13h 50m • 1 change

Frequently asked questions

Want to know about travelling from Effingham to Louisville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Effingham to Louisville.ExpandLaunch map view
  • Distance: 257.6 mi
  • Duration: 6h 8m

What companies run services between Effingham, IL, USA and Louisville, KY, USA?

You can take a bus from Effingham to Louisville Bus Station via Indianapolis Union Station in around 5h 30m.

Operators