The average bus between Eskişehir and Istanbul takes 5h 47m and the fastest bus takes 5h. There is an hourly bus service from Eskişehir to Istanbul. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Eskişehir and Istanbul. The earliest departure is at 2:00 AM at night, and the last departure from Eskişehir is at 11:59 PM which arrives into Istanbul at 5:45 AM. All services require a transfer at Bursa bus station and take an average of 5h 47m. The schedules shown below are for the next available departures.

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5h 30m • 1 changeWant to know about travelling from Eskişehir to Istanbul? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Eskişehir to Istanbul. However, there are services departing from Eskişehir bus station and arriving at Esenler Otogar station via Bursa bus station. The journey, including transfers, takes approximately 5h 47m.
Eskişehir to Istanbul bus services, operated by Kamil Koç, depart from Eskişehir bus station.
Eskişehir to Istanbul bus services, operated by Villa Seyahat, arrive at Esenler Otogar station.
Book your Eskişehir to Istanbul bus tickets online with Omio.
The distance between Eskişehir and Istanbul is 191.4 km. The road distance is 257 km.
You can take a bus from Eskişehir bus station to Esenler Otogar via Bursa bus station and Bursa in around 4h 17m.