Eskişehir to Istanbul Otogar Buses

Trip Overview

The average bus between Eskişehir and Istanbul Otogar takes 5h 42m and the fastest bus takes 5h. There is an hourly bus service from Eskişehir to Istanbul Otogar. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 42m
Duration: 318 km
Distance: ₺1,341
Average price: Hourly
Frequency

Bus via Bursa

best

Take the bus from Eskişehir bus station to Bursa bus stationbus FlixBus KK1618 / ...
Take the bus from Bursa to Esenler Otogarbus

4h 18m

₺529–2,211

Eskişehir to Istanbul Otogar bus times

Buses run hourly between Eskişehir and Istanbul Otogar. The earliest departure is at 2:00 AM at night, and the last departure from Eskişehir is at 11:59 PM which arrives into Istanbul Otogar at 6:00 AM. All services require a transfer at Bursa bus station and take an average of 5h 42m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

4:30 PM → 10:00 PM
5h 30m • 1 change
6:00 PM → 11:30 PM
5h 30m • 1 change
6:30 PM → 11:59 PM
5h 29m • 1 change
7:00 PM → 12:20 AM
Arrives next day
5h 20m • 1 change
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Departing Tuesday, November 10, 2026

2:00 AM → 7:31 AM
5h 31m • 1 change
2:30 AM → 8:25 AM
5h 55m • 1 change
4:00 AM → 10:00 AM
6h • 1 change
5:30 AM → 10:30 AM
5h • 1 change
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Departing Wednesday, November 11, 2026

2:00 AM → 7:31 AM
5h 31m • 1 change
2:30 AM → 8:25 AM
5h 55m • 1 change
4:00 AM → 10:00 AM
6h • 1 change
5:30 AM → 10:30 AM
5h • 1 change
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Departing Thursday, November 12, 2026

2:00 AM → 7:31 AM
5h 31m • 1 change
2:30 AM → 8:25 AM
5h 55m • 1 change
4:00 AM → 10:00 AM
6h • 1 change
5:30 AM → 10:30 AM
5h • 1 change
Show more

Departing Friday, November 13, 2026

2:00 AM → 7:31 AM
5h 31m • 1 change
2:30 AM → 8:25 AM
5h 55m • 1 change
4:00 AM → 10:00 AM
6h • 1 change
5:30 AM → 10:30 AM
5h • 1 change
Show more

Departing Saturday, November 14, 2026

2:00 AM → 7:31 AM
5h 31m • 1 change
2:30 AM → 8:25 AM
5h 55m • 1 change
3:00 AM → 9:00 AM
6h • 1 change
4:00 AM → 10:00 AM
6h • 1 change
Show more

Departing Sunday, November 15, 2026

2:00 AM → 7:31 AM
5h 31m • 1 change
2:30 AM → 8:25 AM
5h 55m • 1 change
3:00 AM → 9:00 AM
6h • 1 change
4:00 AM → 10:00 AM
6h • 1 change
Show more

Departing Monday, November 16, 2026

2:30 AM → 9:00 AM
6h 30m • 1 change
4:30 AM → 10:30 AM
6h • 1 change
5:30 AM → 12:30 PM
7h • 1 change

Frequently asked questions

Want to know about travelling from Eskişehir to Istanbul Otogar? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.