Bus Esplanade de La Défense Station to Lyon from €50 | Tickets & Timetables

Esplanade de La Défense Station to Lyon buses

Travel from

Search accommodation with Expedia

Trip Overview

The average bus between Esplanade de La Défense Station and Lyon takes 6h 23m and the fastest bus takes 5h 44m. The bus service runs several times per day from Esplanade de La Défense Station to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 23m

Duration

472 km

Distance

€50

Average price

4 times a day

Frequency

Esplanade de La Défense Station to Lyon bus times

Buses run 4 times a day between Esplanade de La Défense Station and Lyon. The earliest departure is at 5:05 AM in the morning, and the last departure from Esplanade de La Défense Station is at 10:49 PM which arrives into Lyon at 4:50 AM. All services require a transfer at Porte Maillot - Palais des Congrès and take an average of 6h 23m. The schedules shown below are for the next available departures.

Departing Monday, August 24, 2026

9:10 PM → 3:10 AM
Arrives next day
6h • 1 change
10:46 PM → 4:50 AM
Arrives next day
6h 4m • 1 change

Departing Tuesday, August 25, 2026

6:14 AM → 12:35 PM
6h 21m • 1 change
2:50 PM → 9:40 PM
6h 50m • 1 change
9:10 PM → 3:10 AM
Arrives next day
6h • 1 change
10:46 PM → 4:50 AM
Arrives next day
6h 4m • 1 change

Departing Wednesday, August 26, 2026

6:14 AM → 12:35 PM
6h 21m • 1 change
2:50 PM → 9:40 PM
6h 50m • 1 change
9:10 PM → 3:10 AM
Arrives next day
6h • 1 change
10:46 PM → 4:50 AM
Arrives next day
6h 4m • 1 change

Departing Thursday, August 27, 2026

6:14 AM → 12:35 PM
6h 21m • 1 change
2:50 PM → 9:40 PM
6h 50m • 1 change
9:10 PM → 3:10 AM
Arrives next day
6h • 1 change
10:46 PM → 4:50 AM
Arrives next day
6h 4m • 1 change

Departing Friday, August 28, 2026

6:14 AM → 12:35 PM
6h 21m • 1 change
2:50 PM → 9:40 PM
6h 50m • 1 change
9:10 PM → 3:10 AM
Arrives next day
6h • 1 change
10:46 PM → 4:50 AM
Arrives next day
6h 4m • 1 change

Departing Saturday, August 29, 2026

5:05 AM → 12:35 PM
7h 30m • 1 change
3:02 PM → 9:40 PM
6h 38m • 1 change
9:26 PM → 3:10 AM
Arrives next day
5h 44m • 1 change
10:43 PM → 4:50 AM
Arrives next day
6h 7m • 1 change

Departing Sunday, August 30, 2026

5:05 AM → 12:35 PM
7h 30m • 1 change
2:45 PM → 9:40 PM
6h 55m • 1 change
9:05 PM → 3:10 AM
Arrives next day
6h 5m • 1 change
10:49 PM → 4:50 AM
Arrives next day
6h 1m • 1 change

Frequently asked questions

Want to know about travelling from Esplanade de La Défense Station to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.