The average bus between Fiumicino and Isernia takes 3h 23m and the fastest bus takes 3h 15m. The bus service runs several times per day from Fiumicino to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Fiumicino and Isernia. The earliest departure is at 10:00 AM in the morning, and the last departure from Fiumicino is at 7:55 PM which arrives into Isernia at 11:10 PM. All services require a transfer, and take on average 3h 23m. The schedules shown below are for the next available departures.

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Want to know about travelling from Fiumicino to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Fiumicino to Isernia. However, there are services departing from Fiumicino station and arriving at Isernia station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 3h 23m.
Fiumicino to Isernia bus services, operated by FlixBus, depart from Fiumicino Aeroporto T3 station.
Fiumicino to Isernia bus services, operated by FlixBus, arrive at Isernia station.
Book your Fiumicino to Isernia bus tickets online with FlixBus and ATM Azienda di Trasporti Molisana S.p.A..
The distance between Fiumicino and Isernia is 167 km. The road distance is 205 km.
You can take a bus from Fiumicino Aeroporto T3 to Isernia via Roma, Autostazione Tiburtina in around 4h 5m.