The average bus between Flagstaff and Santa Cruz takes 28h 54m and the fastest bus takes 27h 30m. The bus service runs several times per day from Flagstaff to Santa Cruz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Flagstaff and Santa Cruz. The earliest departure is at 3:35 AM at night, and the last departure from Flagstaff is at 1:05 PM which arrives into Santa Cruz at 6:17 PM. All services require a transfer at Los Angeles Union Station and take an average of 28h 54m. The schedules shown below are for the next available departures.
Arrives next day


29h 20m • 2 changes
Arrives next day


29h 16m • 2 changes
Arrives next day


27h 30m • 2 changes
Arrives next day


29h 12m • 2 changes
Want to know about travelling from Flagstaff to Santa Cruz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Flagstaff to Santa Cruz. However, there are services departing from Flagstaff station and arriving at Santa Cruz station via Los Angeles Union Station station. The journey, including transfers, takes approximately 28h 54m.
Flagstaff to Santa Cruz bus services, operated by Greyhound USA, depart from Flagstaff Bus Station.
Flagstaff to Santa Cruz bus services, operated by Greyhound USA, arrive at Soquel Ave & Front station.
The distance between Flagstaff and Santa Cruz is 952.9 km. The road distance is 1,454 km.
You can take a bus from Flagstaff Bus Station to Soquel Ave & Front via Los Angeles Union Station, San Jose Diridon Station, and Diridon Station in around 20h 47m.