The average bus between Florence and Castel Sant'Angelo takes 4h 27m and the fastest bus takes 3h 50m. There is a bus service every few hours from Florence to Castel Sant'Angelo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Florence and Castel Sant'Angelo. The earliest departure is at 2:20 AM at night, and the last departure from Florence is at 11:10 PM which arrives into Castel Sant'Angelo at 5:56 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 4h 27m. The schedules shown below are for the next available departures.

4h 33m • 1 change

4h • 1 change

4h 51m • 1 change

4h 3m • 1 change

4h 33m • 1 change

4h • 1 change

4h 51m • 1 change

4h 3m • 1 change

4h 33m • 1 change

4h 2m • 1 change

4h 8m • 1 change

4h 52m • 1 change
Want to know about travelling from Florence to Castel Sant'Angelo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Florence to Castel Sant'Angelo. However, there are services departing from Florence station and arriving at Castel Sant'Angelo station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 4h 27m.
Florence to Castel Sant'Angelo bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Castel Sant'Angelo bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
The distance between Florence and Castel Sant'Angelo is 231.1 km. The road distance is 286 km.
FlixBus operates a bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina hourly. Tickets cost €23–40 and the journey takes 3h 15m. Three other operators also service this route.