The average bus between Florence and Hotel Ponte Sisto, Rome takes 4h 17m and the fastest bus takes 3h 43m. There is a bus service every few hours from Florence to Hotel Ponte Sisto, Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Florence and Hotel Ponte Sisto, Rome. The earliest departure is at 2:20 AM at night, and the last departure from Florence is at 11:10 PM which arrives into Hotel Ponte Sisto, Rome at 5:41 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 4h 17m. The schedules shown below are for the next available departures.

4h 28m • 1 change

3h 54m • 1 change

4h 45m • 1 change

3h 56m • 1 change

4h 25m • 1 change

3h 57m • 1 change

3h 54m • 1 change

4h 44m • 1 change

4h 25m • 1 change

3h 57m • 1 change

3h 54m • 1 change

4h 44m • 1 change
Want to know about travelling from Florence to Hotel Ponte Sisto, Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Florence to Hotel Ponte Sisto, Rome. However, there are services departing from Florence station and arriving at Hotel Ponte Sisto, Rome station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 4h 17m.
Florence to Hotel Ponte Sisto, Rome bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Hotel Ponte Sisto, Rome bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
The distance between Florence and Hotel Ponte Sisto, Rome is 232.3 km. The road distance is 285 km.
FlixBus operates a bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina hourly. Tickets cost €24–40 and the journey takes 3h 15m. Three other operators also service this route.