Florence to Hotel Ponte Sisto, Rome Buses

Florence to Hotel Ponte Sisto, Rome buses

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Trip Overview

The average bus between Florence and Hotel Ponte Sisto, Rome takes 4h 21m and the fastest bus takes 3h 41m. There is a bus service every few hours from Florence to Hotel Ponte Sisto, Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 21m
Duration: 284 km
Distance: €31
Average price: Hourly
Frequency

Bus

best

Take the bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtinabus 510 / ...

4h 8m

€16–44

Florence to Hotel Ponte Sisto, Rome bus times

Buses run hourly between Florence and Hotel Ponte Sisto, Rome. The earliest departure is at 2:20 AM at night, and the last departure from Florence is at 11:10 PM which arrives into Hotel Ponte Sisto, Rome at 5:57 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 4h 21m. The schedules shown below are for the next available departures.

Departing Wednesday, October 21, 2026

10:00 PM → 5:57 AM
Arrives next day
7h 57m • 1 change

Departing Thursday, October 22, 2026

2:20 AM → 6:41 AM
4h 21m • 1 change
3:35 AM → 7:39 AM
4h 4m • 1 change
4:40 AM → 9:36 AM
4h 56m • 1 change
6:10 AM → 10:16 AM
4h 6m • 1 change
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Departing Friday, October 23, 2026

2:20 AM → 6:41 AM
4h 21m • 1 change
3:35 AM → 7:39 AM
4h 4m • 1 change
3:50 AM → 7:54 AM
4h 4m • 1 change
4:40 AM → 9:36 AM
4h 56m • 1 change
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Departing Saturday, October 24, 2026

2:20 AM → 6:50 AM
4h 30m • 1 change
3:35 AM → 7:29 AM
3h 54m • 1 change
3:50 AM → 7:46 AM
3h 56m • 1 change
4:40 AM → 9:27 AM
4h 47m • 1 change
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Departing Sunday, October 25, 2026

2:20 AM → 5:53 AM
4h 33m • 1 change
2:50 AM → 6:31 AM
3h 41m • 1 change
3:40 AM → 8:15 AM
4h 35m • 1 change
5:00 AM → 8:50 AM
3h 50m • 1 change
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Departing Monday, October 26, 2026

2:20 AM → 6:41 AM
4h 21m • 1 change
3:35 AM → 7:39 AM
4h 4m • 1 change
3:50 AM → 7:54 AM
4h 4m • 1 change
4:40 AM → 9:36 AM
4h 56m • 1 change
Show more

Departing Tuesday, October 27, 2026

2:20 AM → 6:41 AM
4h 21m • 1 change
3:35 AM → 7:39 AM
4h 4m • 1 change
3:50 AM → 7:54 AM
4h 4m • 1 change
4:40 AM → 9:36 AM
4h 56m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Florence to Hotel Ponte Sisto, Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.