The average bus between Florence and Isernia takes 6h 24m and the fastest bus takes 5h 45m. The bus service runs several times per day from Florence to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Florence and Isernia. The earliest departure is at 6:10 AM in the morning, and the last departure from Florence is at 3:50 PM which arrives into Isernia at 11:10 PM. All services require a transfer, and take on average 6h 24m. The schedules shown below are for the next available departures.
Want to know about travelling from Florence to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Florence to Isernia. However, there are services departing from Florence Villa Constanza Bus Station and arriving at Isernia station via Roma, Autostazione Tiburtina station. The journey, including transfers, takes approximately 6h 24m.
Florence to Isernia bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Isernia bus services, operated by ATM Azienda di Trasporti Molisana S.p.A., arrive at Isernia station.
Book your Florence to Isernia bus tickets online with Omio and FlixBus.
The distance between Florence and Isernia is 344.3 km. The road distance is 428 km.
You can take a bus from Florence Villa Constanza Bus Station to Isernia via Roma, Autostazione Tiburtina in around 6h 25m.
