The average bus between Florence and Luzern station takes 9h 43m and the fastest bus takes 8h 35m. The bus service runs several times per day from Florence to Luzern station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Florence and Luzern station. The earliest departure is at 5:15 AM in the morning, and the last departure from Florence is at 7:45 PM which arrives into Luzern station at 2:20 AM. All services require a transfer at Milan and take an average of 9h 43m. The schedules shown below are for the next available departures.

7h 50m • 1 change
Arrives next day

8h • 1 change
Arrives next day

6h 35m • 1 change

9h 10m • 1 change
Arrives next day

8h • 1 change
Arrives next day

8h 10m • 1 change

7h 50m • 1 change
Arrives next day

8h • 1 change
Arrives next day

6h 35m • 1 change
Want to know about travelling from Florence to Luzern station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Florence to Luzern station station. However, there are services departing from Florence station and arriving at Luzern station via Milano, Autostazione Lampugnano. The journey, including transfers, takes approximately 9h 43m.
Florence to Luzern station bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Luzern station bus services, operated by FlixBus, arrive at Luzern station.
Book your Florence to Luzern station bus tickets online with FlixBus, Autolinee Federico and RegioJet.
The distance between Florence and Luzern station is 429.6 km. The road distance is 570 km.
You can take a bus from Florence Villa Constanza Bus Station to Luzern station via Milan and Luzern in around 10h 11m.