The average bus between Florence and Montepulciano takes 6h 29m and the fastest bus takes 4h 13m. The bus service runs several times per day from Florence to Montepulciano. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Florence and Montepulciano. The earliest departure is at 4:40 AM at night, and the last departure from Florence is at 8:05 PM which arrives into Montepulciano at 7:48 AM. All services require a transfer at Siena and take an average of 6h 29m. The schedules shown below are for the next available departures.


5h 28m • 2 changes


4h 18m • 2 changes
Arrives next day


11h 43m • 2 changes


4h 13m • 2 changes


6h 48m • 2 changes


4h 18m • 2 changes
Arrives next day


11h 43m • 2 changes


4h 13m • 2 changes


6h 48m • 2 changes


4h 18m • 2 changes
Arrives next day


13h 38m • 2 changes


4h 13m • 2 changes


6h 48m • 2 changes


4h 18m • 2 changes
Arrives next day


12h 43m • 2 changes
Want to know about travelling from Florence to Montepulciano? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Florence to Montepulciano. However, there are services departing from Florence station and arriving at Montepulciano station via Siena. The journey, including transfers, takes approximately 6h 29m.
Florence to Montepulciano bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Montepulciano bus services, operated by FlixBus, arrive at P.Ta Delle Farine station.
Book your Florence to Montepulciano bus tickets online with FlixBus and Autolinee Toscane.
The distance between Florence and Montepulciano is 87.7 km. The road distance is 141 km.
You can take a bus from Florence Villa Constanza Bus Station to P.Ta Delle Farine via Siena, Siena Autostazione, and Buonconvento in around 4h 10m.