The average bus between Florence and Otranto takes 14h 47m and the fastest bus takes 13h 28m. The bus service runs several times per day from Florence to Otranto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Florence and Otranto. The earliest departure is at 2:20 AM at night, and the last departure from Florence is at 7:45 PM which arrives into Otranto at 11:12 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 14h 47m. The schedules shown below are for the next available departures.
Arrives next day


13h 28m • 2 changes
Arrives next day


15h 27m • 2 changes


15h 25m • 2 changes
Arrives next day


13h 28m • 2 changes
Arrives next day


15h 27m • 2 changes


14h 45m • 2 changes


15h 25m • 2 changes
Arrives next day


13h 28m • 2 changes
Arrives next day


15h 27m • 2 changes


14h 45m • 2 changes


15h 25m • 2 changes
Arrives next day


13h 28m • 2 changes
Arrives next day


15h 27m • 2 changes


14h 45m • 2 changes


15h 25m • 2 changes
Arrives next day


13h 28m • 2 changes
Arrives next day


15h 27m • 2 changes
Want to know about travelling from Florence to Otranto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Florence to Otranto. However, there are services departing from Florence station and arriving at Otranto station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 14h 47m.
Florence to Otranto bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Otranto bus services, operated by FlixBus, arrive at Otranto - Stazione FSE station.
Book your Florence to Otranto bus tickets online with FlixBus and Salento in bus.
The distance between Florence and Otranto is 721.6 km. The road distance is 941 km.
You can take a bus from Florence Villa Constanza Bus Station to Otranto - Stazione FSE via Roma, Autostazione Tiburtina and Lecce - City Terminal in around 15h 17m.