The average bus between Florence and Sicily takes 17h 37m and the fastest bus takes 17h 27m. The bus service runs several times per day from Florence to Sicily. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Florence and Sicily. The earliest departure is at 6:00 PM in the evening, and the last departure from Florence is at 10:00 PM which arrives into Sicily at 3:45 PM. All services require a transfer at Palermo and take an average of 17h 37m. The schedules shown below are for the next available departures.
Arrives next day

17h 33m • 1 change
Arrives next day

17h 45m • 1 change
Arrives next day

17h 33m • 1 change
Arrives next day

17h 45m • 1 change
Arrives next day

17h 27m • 1 change
Arrives next day

17h 42m • 1 change
Arrives next day

17h 27m • 1 change
Arrives next day

17h 42m • 1 change
Want to know about travelling from Florence to Sicily? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Florence to Sicily. However, there are services departing from Florence station and arriving at Sicily station via Palermo. The journey, including transfers, takes approximately 17h 37m.
Florence to Sicily bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Sicily bus services, operated by FlixBus, arrive at Palermo station.
The distance between Florence and Sicily is 730.7 km. The road distance is 1,278 km.
FlixBus operates a bus from Florence Villa Constanza Bus Station to Palermo twice daily. Tickets cost €110–180 and the journey takes 17h.