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Florence to Sistine Chapel buses

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Trip Overview

The average bus between Florence and Sistine Chapel takes 4h 35m and the fastest bus takes 3h 55m. There is a bus service every few hours from Florence to Sistine Chapel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 35m
Duration
287 km
Distance
€30
Average price
Hourly
Frequency

Bus

best
  1. Take the bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtinabus bus 510 / ...
4h 25m
€16–43

Florence to Sistine Chapel bus times

Buses run hourly between Florence and Sistine Chapel. The earliest departure is at 2:20 AM at night, and the last departure from Florence is at 11:10 PM which arrives into Sistine Chapel at 5:59 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 4h 35m. The schedules shown below are for the next available departures.

Departing Thursday, October 8, 2026

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 24m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 18m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 36m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 39m • 1 change
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Departing Friday, October 9, 2026

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 29m • 1 change

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    Itabus S.p.A.ATAC S.p.A. Azienda per la mobilità4h 13m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 13m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità5h 7m • 1 change
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Departing Saturday, October 10, 2026

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 36m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 4m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 55m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 8m • 1 change
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Departing Sunday, October 11, 2026

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 36m • 1 change

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    Itabus S.p.A.ATAC S.p.A. Azienda per la mobilità4h 6m • 1 change

Frequently asked questions

Want to know about travelling from Florence to Sistine Chapel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Sistine Chapel.ExpandLaunch map view
  • Distance: 287.4 km
  • Duration: 4h 35m

What companies run services between Florence, Italy and Sistine Chapel, Vatican City?

FlixBus operates a bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina hourly. Tickets cost €22–35 and the journey takes 3h 15m. Three other operators also service this route.

Operators