Florence to Sistine Chapel bus times
Buses run hourly between Florence and Sistine Chapel. The earliest departure is at 2:20 AM at night, and the last departure from Florence is at 10:00 PM which arrives into Sistine Chapel at 6:02 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 4h 32m. The schedules shown below are for the next available departures.
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4h 9m • 1 change
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4h 34m • 1 change
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3h 57m • 1 change
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4h 10m • 1 change
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Departing Tuesday, August 11, 2026
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4h 38m • 1 change
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4h 20m • 1 change
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4h 57m • 1 change
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4h 9m • 1 change
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Departing Wednesday, August 12, 2026
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4h 38m • 1 change
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4h 20m • 1 change
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4h 57m • 1 change
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4h 9m • 1 change
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