The average bus between Florence and Vatican City takes 4h 23m and the fastest bus takes 3h 48m. There is a bus service every few hours from Florence to Vatican City. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Florence and Vatican City. The earliest departure is at 2:20 AM at night, and the last departure from Florence is at 11:10 PM which arrives into Vatican City at 5:55 AM. All services require a transfer, and take on average 4h 23m. The schedules shown below are for the next available departures.

4h 29m • 1 change

4h 5m • 1 change

3h 54m • 1 change

4h 42m • 1 change

4h 34m • 1 change

4h 11m • 1 change

4h 6m • 1 change

4h 54m • 1 change

4h 34m • 1 change

4h 11m • 1 change

4h 6m • 1 change

4h 54m • 1 change
Want to know about travelling from Florence to Vatican City? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Florence to Vatican City. However, there are services departing from Florence station and arriving at Vatican City station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 4h 23m.
Florence to Vatican City bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Vatican City bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Book your Florence to Vatican City bus tickets online with FlixBus, ATAC S.p.A. Azienda per la mobilità and Itabus S.p.A..
The distance between Florence and Vatican City is 230.6 km. The road distance is 286 km.
FlixBus operates a bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina hourly. Tickets cost €24–40 and the journey takes 3h 15m. Three other operators also service this route.