Florence to Vatican City Relais, Rome Buses

Trip Overview

The average bus between Florence and Vatican City Relais, Rome takes 4h 24m and the fastest bus takes 3h 53m. There is a bus service every few hours from Florence to Vatican City Relais, Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 24m
Duration: 288 km
Distance: €31
Average price: Hourly
Frequency

Bus

best

Take the bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtinabus 510 / ...

4h 22m

€16–44

Florence to Vatican City Relais, Rome bus times

Buses run hourly between Florence and Vatican City Relais, Rome. The earliest departure is at 2:20 AM at night, and the last departure from Florence is at 11:10 PM which arrives into Vatican City Relais, Rome at 5:51 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 4h 24m. The schedules shown below are for the next available departures.

Departing Thursday, October 22, 2026

1:05 PM → 5:25 PM
4h 20m • 1 change
2:10 PM → 6:43 PM
4h 33m • 1 change
3:35 PM → 7:44 PM
4h 9m • 1 change
4:45 PM → 9:24 PM
4h 39m • 1 change
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Departing Friday, October 23, 2026

2:20 AM → 6:51 AM
4h 31m • 1 change
3:35 AM → 7:49 AM
4h 14m • 1 change
3:50 AM → 7:58 AM
4h 8m • 1 change
4:40 AM → 9:34 AM
4h 54m • 1 change
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Departing Saturday, October 24, 2026

2:20 AM → 6:47 AM
4h 27m • 1 change
3:50 AM → 7:43 AM
3h 53m • 1 change
4:40 AM → 9:26 AM
4h 46m • 1 change
6:00 AM → 10:06 AM
4h 6m • 1 change
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Departing Sunday, October 25, 2026

2:20 AM → 6:01 AM
4h 41m • 1 change
2:50 AM → 6:55 AM
4h 5m • 1 change
3:40 AM → 8:29 AM
4h 49m • 1 change
5:10 AM → 9:13 AM
4h 3m • 1 change
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Departing Monday, October 26, 2026

2:20 AM → 6:51 AM
4h 31m • 1 change
3:35 AM → 7:49 AM
4h 14m • 1 change
3:50 AM → 7:58 AM
4h 8m • 1 change
4:40 AM → 9:34 AM
4h 54m • 1 change
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Departing Tuesday, October 27, 2026

2:20 AM → 6:51 AM
4h 31m • 1 change
3:35 AM → 7:49 AM
4h 14m • 1 change
3:50 AM → 7:58 AM
4h 8m • 1 change
4:40 AM → 9:34 AM
4h 54m • 1 change
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Departing Wednesday, October 28, 2026

2:20 AM → 6:51 AM
4h 31m • 1 change
3:35 AM → 7:49 AM
4h 14m • 1 change
4:40 AM → 9:34 AM
4h 54m • 1 change
6:00 AM → 10:07 AM
4h 7m • 1 change
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Frequently asked questions

Want to know about travelling from Florence to Vatican City Relais, Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.