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Florence to Vatican Museums buses

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Trip Overview

The average bus between Florence and Vatican Museums takes 4h 19m and the fastest bus takes 3h 45m. There is a bus service every few hours from Florence to Vatican Museums. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 19m
Duration
285 km
Distance
€30
Average price
Hourly
Frequency

Bus

best
  1. Take the bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtinabus bus 510 / ...
4h 8m
€16–43

Florence to Vatican Museums bus times

Buses run hourly between Florence and Vatican Museums. The earliest departure is at 2:20 AM at night, and the last departure from Florence is at 11:10 PM which arrives into Vatican Museums at 5:44 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 4h 19m. The schedules shown below are for the next available departures.

Departing Friday, October 9, 2026

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 26m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 13m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 27m • 1 change
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Departing Saturday, October 10, 2026

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 19m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità3h 45m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 44m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità3h 57m • 1 change
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Departing Sunday, October 11, 2026

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 30m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità3h 49m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 52m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 4m • 1 change
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Departing Monday, October 12, 2026

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 23m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità3h 57m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 43m • 1 change

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    FlixBusATAC S.p.A. Azienda per la mobilità4h 6m • 1 change

Frequently asked questions

Want to know about travelling from Florence to Vatican Museums? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Vatican Museums.ExpandLaunch map view
  • Distance: 285.3 km
  • Duration: 4h 19m

What companies run services between Florence, Italy and Vatican Museums, Vatican City?

FlixBus operates a bus from Florence Villa Constanza Bus Station to Roma, Autostazione Tiburtina hourly. Tickets cost €22–35 and the journey takes 3h 15m. Three other operators also service this route.

Operators