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Florence to Chicago buses

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Trip Overview

The average bus between Florence and Chicago takes 8h 34m and the fastest bus takes 7h 50m. There is at least one bus per day from Florence to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

8h 34m
Duration
314 mi
Distance
$62
Average price
Once daily
Frequency

Florence to Chicago bus times

Buses run once daily between Florence and Chicago. The earliest departure is at 12:10 AM at night, and the last departure from Florence is at 11:40 AM which arrives into Chicago at 6:55 PM. All services require a transfer at 4th at Walnut and take an average of 8h 34m. The schedules shown below are for the next available departures.

Departing Monday, November 2, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA8h 15m • 3 changes

Departing Wednesday, November 4, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA7h 50m • 3 changes

Departing Thursday, November 5, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA7h 50m • 3 changes
  •  → 

    TANKGo MetroGo MetroFlixbus USA8h 15m • 3 changes

Departing Friday, November 6, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA7h 50m • 3 changes
  •  → 

    TANKGo MetroGo MetroFlixbus USA8h 15m • 3 changes

Departing Saturday, November 7, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA12h 50m • 3 changes

Frequently asked questions

Want to know about travelling from Florence to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Chicago.ExpandLaunch map view
  • Distance: 313.9 mi
  • Duration: 8h 34m

What companies run services between Florence, KY, USA and Chicago, IL, USA?

Flixbus USA operates a bus from Cincinnati to Chicago Bus Station twice daily. Tickets cost $45–70 and the journey takes 6h.

Operators