Rome2Rio

Florence to Chicago buses

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Trip Overview

The average bus between Florence and Chicago takes 8h 42m and the fastest bus takes 7h 50m. The bus service runs several times per day from Florence to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

8h 42m
Duration
314 mi
Distance
$62
Average price
Twice daily
Frequency

Florence to Chicago bus times

Buses run twice daily between Florence and Chicago. The earliest departure is at 12:10 AM at night, and the last departure from Florence is at 11:10 PM which arrives into Chicago at 12:00 PM. All services require a transfer at 4th at Walnut and take an average of 8h 42m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA7h 50m • 3 changes
  •  → 

    TANKGo MetroGo MetroFlixbus USA8h 15m • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA7h 50m • 3 changes
  •  → 

    TANKGo MetroGo MetroFlixbus USA8h 15m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA7h 50m • 3 changes
  •  → 

    TANKGo MetroGo MetroFlixbus USA8h 15m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA12h 50m • 3 changes
  •  → 

    TANKGo MetroGo MetroFlixbus USA8h 15m • 3 changes
  •  → 

    Arrives next day

    TANKGo MetroGo MetroFlixbus USA13h 50m • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA8h 15m • 3 changes

Departing Monday, November 16, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA7h 50m • 3 changes
  •  → 

    TANKGo MetroGo MetroFlixbus USA8h 15m • 3 changes

Departing Tuesday, November 17, 2026

  •  → 

    TANKGo MetroGo MetroFlixbus USA7h 50m • 3 changes
  •  → 

    TANKGo MetroGo MetroFlixbus USA8h 15m • 3 changes
  •  → 

    TANKGo MetroGo MetroFlixbus USA7h 50m • 3 changes

Frequently asked questions

Want to know about travelling from Florence to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Chicago.ExpandLaunch map view
  • Distance: 313.9 mi
  • Duration: 8h 42m

What companies run services between Florence, KY, USA and Chicago, IL, USA?

Flixbus USA operates a bus from Cincinnati to Chicago Bus Station twice daily. Tickets cost $45–70 and the journey takes 6h.

Operators