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Florence to Buffalo buses

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Trip Overview

The average bus between Florence and Buffalo takes 25h 46m and the fastest bus takes 25h 40m. The bus runs, on average, 4 times per week from Florence to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

25h 46m
Duration
1,031 mi
Distance
$204
Average price
4 times a week
Frequency

Florence to Buffalo bus times

Buses run 4 times a week between Florence and Buffalo. The service departs Florence at 3:20 PM in the afternoon, which arrives into Buffalo at 17:00:00. All services require a transfer at Fayetteville Bus Station and take an average of 25h 46m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA25h 40m • 2 changes

Departing Monday, November 9, 2026

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    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA26h 5m • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA25h 40m • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA25h 40m • 2 changes

Frequently asked questions

Want to know about travelling from Florence to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Buffalo.ExpandLaunch map view
  • Distance: 1,030.7 mi
  • Duration: 25h 46m

What companies run services between Florence, SC, USA and Buffalo, NY, USA?

You can take a bus from Florence Bus Station to Buffalo via Fayetteville Bus Station and Newark Penn Station in around 21h 28m.

Operators