Rome2Rio

Florence to Charlotte buses

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Trip Overview

The bus between Florence and Charlotte takes 4h 50m. There is at least one bus per day from Florence to Charlotte. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 50m
Duration
127 mi
Distance
$27
Average price
Once daily
Frequency

Florence to Charlotte bus times

Buses run once daily between Florence and Charlotte. The service departs Florence at 12:05 PM in the afternoon, which arrives into Charlotte at 16:55:00. All services require a transfer, and take on average 4h 50m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Thursday, November 12, 2026

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    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Friday, November 13, 2026

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    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Saturday, November 14, 2026

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    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Sunday, November 15, 2026

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    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Monday, November 16, 2026

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    Greyhound USAGreyhound USA4h 50m • 1 change

Departing Tuesday, November 17, 2026

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    Greyhound USAGreyhound USA4h 50m • 1 change

Frequently asked questions

Want to know about travelling from Florence to Charlotte? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Charlotte.ExpandLaunch map view
  • Distance: 126.8 mi
  • Duration: 4h 50m

What companies run services between Florence, SC, USA and Charlotte, NC, USA?

You can take a bus from Florence Bus Station to Charlotte Bus Station via Camden in around 3h 40m.

Operators