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Florence to Des Moines buses

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Trip Overview

The bus between Florence and Des Moines takes 31h 50m. The bus runs, on average, 6 times per week from Florence to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

31h 50m
Duration
1,299 mi
Distance
$285
Average price
6 times a week
Frequency

Florence to Des Moines bus times

Buses run 6 times a week between Florence and Des Moines. The service departs Florence at 2:55 PM in the afternoon, which arrives into Des Moines at 21:45:00. All services require a transfer at Atlanta Bus Station and take an average of 31h 50m. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA31h 50m • 2 changes

Departing Wednesday, November 4, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA31h 50m • 2 changes

Departing Thursday, November 5, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA31h 50m • 2 changes

Departing Friday, November 6, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA31h 50m • 2 changes

Departing Saturday, November 7, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA31h 50m • 2 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA31h 50m • 2 changes

Frequently asked questions

Want to know about travelling from Florence to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Des Moines.ExpandLaunch map view
  • Distance: 1,299.2 mi
  • Duration: 31h 50m

What companies run services between Florence, SC, USA and Des Moines, IA, USA?

You can take a bus from Florence Bus Station to Des Moines via Atlanta Bus Station and Indianapolis Union Station in around 30h 20m.

Operators