Rome2Rio

Florence to Frederick buses

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Trip Overview

The bus between Florence and Frederick takes 17h 10m. The bus runs, on average, 6 times per week from Florence to Frederick. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

17h 10m
Duration
456 mi
Distance
$97
Average price
6 times a week
Frequency

Florence to Frederick bus times

Buses run 6 times a week between Florence and Frederick. The service departs Florence at 3:20 PM in the afternoon, which arrives into Frederick at 08:30:00. All services require a transfer at Raleigh Bus Station and take an average of 17h 10m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA17h 10m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA17h 10m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA17h 10m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA17h 10m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA17h 10m • 2 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA17h 10m • 2 changes

Frequently asked questions

Want to know about travelling from Florence to Frederick? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Frederick.ExpandLaunch map view
  • Distance: 456.3 mi
  • Duration: 17h 10m

What companies run services between Florence, SC, USA and Frederick, MD, USA?

You can take a bus from Florence Bus Station to Frederick Bus Station via Raleigh Bus Station and Washington Union Station in around 10h 55m.

Operators