Rome2Rio

Florence to Indianapolis buses

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Trip Overview

The average bus between Florence and Indianapolis takes 24h 47m and the fastest bus takes 19h 50m. The bus service runs several times per day from Florence to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

24h 47m
Duration
864 mi
Distance
$173
Average price
Twice daily
Frequency

Florence to Indianapolis bus times

Buses run twice daily between Florence and Indianapolis. The earliest departure is at 12:05 PM in the afternoon, and the last departure from Florence is at 2:55 PM which arrives into Indianapolis at 9:40 PM. All services require a transfer, and take on average 24h 47m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAFlixbus USA19h 50m • 1 change
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    Arrives next day

    Greyhound USAFlixbus USA30h 45m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA19h 50m • 1 change
  •  → 

    Arrives next day

    Greyhound USAFlixbus USA30h 45m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA19h 50m • 1 change
  •  → 

    Arrives next day

    Greyhound USAFlixbus USA30h 45m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA19h 50m • 1 change
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    Arrives next day

    Greyhound USAFlixbus USA30h 45m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA19h 50m • 1 change
  •  → 

    Arrives next day

    Greyhound USAFlixbus USA30h 45m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA19h 50m • 1 change

Frequently asked questions

Want to know about travelling from Florence to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Indianapolis.ExpandLaunch map view
  • Distance: 864.5 mi
  • Duration: 24h 47m

What companies run services between Florence, SC, USA and Indianapolis, IN, USA?

You can take a bus from Florence Bus Station to Indianapolis via Atlanta Bus Station in around 19h 20m.

Operators