Rome2Rio

Florence to Key Largo buses

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Trip Overview

The bus between Florence and Key Largo takes 39h 5m. The bus runs, on average, 2 times per week from Florence to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

39h 5m
Duration
922 mi
Distance
$181
Average price
Twice a week
Frequency

Florence to Key Largo bus times

Buses run twice a week between Florence and Key Largo. The service departs Florence at 3:20 PM in the afternoon, which arrives into Key Largo at 06:25:00. All services require a transfer at Fayetteville Bus Station and take an average of 39h 5m. The schedules shown below are for the next available departures.

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA39h 5m • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA39h 5m • 2 changes

Frequently asked questions

Want to know about travelling from Florence to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Key Largo.ExpandLaunch map view
  • Distance: 922.1 mi
  • Duration: 39h 5m

What companies run services between Florence, SC, USA and Key Largo, FL, USA?

You can take a bus from Florence Bus Station to Key Largo Bus Stop via Fayetteville Bus Station and Miami Airport Station in around 20h 15m.

Operators