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Florence to Roanoke buses

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Trip Overview

The bus between Florence and Roanoke takes 44h 39m. The bus runs, on average, 4 times per week from Florence to Roanoke. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

44h 39m
Duration
430 mi
Distance
$89
Average price
4 times a week
Frequency

Florence to Roanoke bus times

Buses run 4 times a week between Florence and Roanoke. The service departs Florence at 3:20 PM in the afternoon, which arrives into Roanoke at 11:59:00. All services require a transfer at Raleigh Bus Station and take an average of 44h 39m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USAGreyhound USA44h 39m • 3 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USAGreyhound USA44h 39m • 3 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USAGreyhound USA44h 39m • 3 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USAGreyhound USA44h 39m • 3 changes

Frequently asked questions

Want to know about travelling from Florence to Roanoke? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Roanoke.ExpandLaunch map view
  • Distance: 430.3 mi
  • Duration: 44h 39m

What companies run services between Florence, SC, USA and Roanoke, VA, USA?

You can take a bus from Florence Bus Station to Roanoke Bus Stop via Raleigh Bus Station, Greensboro Bus Stop, and Lynchburg Transit Center in around 12h 34m.

Operators