Rome2Rio

Florence to St. Louis buses

Find Transport to St. Louis

View schedule
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

Trip Overview

The bus between Florence and St. Louis takes 19h 25m. The bus runs, on average, 4 times per week from Florence to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

19h 25m
Duration
850 mi
Distance
$166
Average price
4 times a week
Frequency

Florence to St. Louis bus times

Buses run 4 times a week between Florence and St. Louis. The service departs Florence at 2:55 PM in the afternoon, which arrives into St. Louis at 09:20:00. All services require a transfer at Atlanta Bus Station and take an average of 19h 25m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA19h 25m • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA19h 25m • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA19h 25m • 2 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAFlixbus USA19h 25m • 2 changes

Frequently asked questions

Want to know about travelling from Florence to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to St. Louis.ExpandLaunch map view
  • Distance: 850 mi
  • Duration: 19h 25m

What companies run services between Florence, SC, USA and St. Louis, MO, USA?

You can take a bus from Florence Bus Station to St. Louis via Atlanta Bus Station and Carbondale in around 19h 1m.

Operators