The average bus between Florence and Syracuse takes 23h 37m and the fastest bus takes 22h 25m. The bus service runs several times per day from Florence to Syracuse. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Florence and Syracuse. The earliest departure is at 3:20 PM in the afternoon, and the last departure from Florence is at 7:20 PM which arrives into Syracuse at 8:10 PM. All services require a transfer at New York, NY and take an average of 23h 37m. The schedules shown below are for the next available departures.
Arrives next day


22h 25m • 2 changes
Arrives next day


24h 50m • 2 changes
Arrives next day


22h 25m • 2 changes
Arrives next day


24h 50m • 2 changes
Arrives next day


22h 25m • 2 changes
Arrives next day


24h 50m • 2 changes
Arrives next day


22h 25m • 2 changes
Arrives next day


24h 50m • 2 changes
Want to know about travelling from Florence to Syracuse? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Florence to Syracuse. However, there are services departing from Florence station and arriving at Syracuse station via New York, NY. The journey, including transfers, takes approximately 23h 37m.
Florence to Syracuse bus services, operated by Greyhound USA, depart from Florence, SC station.
Florence to Syracuse bus services, operated by Greyhound USA, arrive at Syracuse Bus Station.
Book your Florence to Syracuse bus tickets online with Greyhound USA.
The distance between Florence and Syracuse is 1,033 km. The road distance is 1,551 km.
You can take a bus from Florence, SC to Syracuse Bus Station via New York, NY, Delancey St-Essex St, 23 St, and New York Midtown in around 18h 46m.