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Fort Myers Beach to Florida Keys buses

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Trip Overview

The average bus between Fort Myers Beach and Florida Keys takes 20h 49m and the fastest bus takes 20h. The bus runs, on average, 6 times per week from Fort Myers Beach to Florida Keys. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

20h 49m
Duration
324 mi
Distance
$70
Average price
6 times a week
Frequency

Fort Myers Beach to Florida Keys bus times

Buses run 6 times a week between Fort Myers Beach and Florida Keys. The earliest departure is at 1:57 PM in the afternoon, and the last departure from Fort Myers Beach is at 4:14 PM which arrives into Florida Keys at 12:15 PM. All services require a transfer at Beach Park & Ride and take an average of 20h 49m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit22h 17m • 5 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit20h • 5 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit20h • 5 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit21h 19m • 5 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit21h 19m • 5 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit20h • 5 changes

Frequently asked questions

Want to know about travelling from Fort Myers Beach to Florida Keys? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Fort Myers Beach to Florida Keys.ExpandLaunch map view
  • Distance: 323.6 mi
  • Duration: 20h 49m

What companies run services between Fort Myers Beach, FL, USA and Florida Keys, FL, USA?

You can take a bus from Crescent St @ Estero Blvd to Florida Keys via Beach Park & Ride, Edison Mall Transfer Ctr, Fort Myers Bus Stop, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 12h 45m.

Operators