Rome2Rio

Fort Myers Beach to Key West, FL buses

Find Transport to Key West, FL

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Trip Overview

The average bus between Fort Myers Beach and Key West, FL takes 21h 44m and the fastest bus takes 20h 55m. The bus runs, on average, 6 times per week from Fort Myers Beach to Key West, FL. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

21h 44m
Duration
343 mi
Distance
$70
Average price
6 times a week
Frequency

Fort Myers Beach to Key West, FL bus times

Buses run 6 times a week between Fort Myers Beach and Key West, FL. The earliest departure is at 1:57 PM in the afternoon, and the last departure from Fort Myers Beach is at 4:14 PM which arrives into Key West, FL at 1:10 PM. All services require a transfer at Beach Park & Ride and take an average of 21h 44m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit20h 55m • 5 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit23h 12m • 5 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit20h 55m • 5 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit20h 55m • 5 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit22h 14m • 5 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Lee County TransitLee County TransitLee County TransitFlixbus USAGreyhound USAKey West Transit22h 14m • 5 changes

Frequently asked questions

Want to know about travelling from Fort Myers Beach to Key West, FL? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Fort Myers Beach to Key West, FL.ExpandLaunch map view
  • Distance: 342.8 mi
  • Duration: 21h 44m

What companies run services between Fort Myers Beach, FL, USA and Key West, FL, USA?

You can take a bus from Crescent St @ Estero Blvd to Whitehead & Eaton via Beach Park & Ride, Edison Mall Transfer Ctr, Fort Myers Bus Stop, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 13h 39m.

Operators