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Fort Myers to Des Moines buses

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Trip Overview

The bus between Fort Myers and Des Moines takes 2d 10h. The bus runs, on average, 4 times per week from Fort Myers to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 10h
Duration
1,650 mi
Distance
$334
Average price
4 times a week
Frequency

Fort Myers to Des Moines bus times

Buses run 4 times a week between Fort Myers and Des Moines. The service departs Fort Myers at 12:20 PM in the afternoon, which arrives into Des Moines at 21:45:00. All services require a transfer at Tampa Bus Station and take an average of 2d 10h. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAGreyhound USAGreyhound USA2d 10h • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAGreyhound USAGreyhound USA2d 10h • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAGreyhound USAGreyhound USA2d 10h • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAGreyhound USAGreyhound USA2d 10h • 3 changes

Frequently asked questions

Want to know about travelling from Fort Myers to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Fort Myers to Des Moines.ExpandLaunch map view
  • Distance: 1,650 mi
  • Duration: 2d 10h

What companies run services between Fort Myers, FL, USA and Des Moines, IA, USA?

You can take a bus from Fort Myers Bus Stop to Des Moines via Tampa Bus Station, Atlanta Bus Station, and Indianapolis Union Station in around 36h 50m.

Operators