Rome2Rio

Fort Myers to Key West, FL buses

Find Transport to Key West, FL

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Trip Overview

The average bus between Fort Myers and Key West, FL takes 20h 3m and the fastest bus takes 18h 40m. There is at least one bus per day from Fort Myers to Key West, FL. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

20h 3m
Duration
319 mi
Distance
$61
Average price
Once daily
Frequency

Fort Myers to Key West, FL bus times

Buses run once daily between Fort Myers and Key West, FL. The earliest departure is at 4:45 PM in the afternoon, and the last departure from Fort Myers is at 6:30 PM which arrives into Key West, FL at 1:10 PM. All services require a transfer at Miami Airport Station and take an average of 20h 3m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit20h 25m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit18h 40m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit18h 40m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit18h 40m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit18h 40m • 2 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Flixbus USAGreyhound USAKey West Transit18h 40m • 2 changes

Frequently asked questions

Want to know about travelling from Fort Myers to Key West, FL? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Fort Myers to Key West, FL.ExpandLaunch map view
  • Distance: 318.9 mi
  • Duration: 20h 3m

What companies run services between Fort Myers, FL, USA and Key West, FL, USA?

You can take a bus from Fort Myers Bus Stop to Whitehead & Eaton via Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 10h 9m.

Operators