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Fort Myers to Lake City buses

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Trip Overview

The average bus between Fort Myers and Lake City takes 15h 1m and the fastest bus takes 14h 5m. There is at least one bus per day from Fort Myers to Lake City. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 1m
Duration
312 mi
Distance
$106
Average price
Once daily
Frequency

Fort Myers to Lake City bus times

Buses run once daily between Fort Myers and Lake City. The service departs Fort Myers at 6:55 PM in the evening, which arrives into Lake City at 09:00:00. All services require a transfer at Fort Myers 7-11 and take an average of 15h 1m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Flixbus USAGreyhound USA14h 5m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    Flixbus USAGreyhound USA14h 5m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA14h 5m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA14h 5m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA14h 5m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USA14h 5m • 1 change

Frequently asked questions

Want to know about travelling from Fort Myers to Lake City? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Fort Myers to Lake City.ExpandLaunch map view
  • Distance: 312.4 mi
  • Duration: 15h 1m

What companies run services between Fort Myers, FL, USA and Lake City, FL, USA?

You can take a vehicle from Fort Myers to Lake City Bus Station via Fort Myers 7-11, University of Florida - 1956 Gale Lemerand Dr, UF Health Archer Road, North Walmart Supercenter, and Gainesville Bus Stop in around 8h 48m.

Operators