The average bus between Frankfurt am Main and Wertheim takes 3h 25m and the fastest bus takes 2h 43m. The bus service runs several times per day from Frankfurt am Main to Wertheim. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Frankfurt am Main and Wertheim. The earliest departure is at 4:50 AM at night, and the last departure from Frankfurt am Main is at 10:00 PM which arrives into Wertheim at 12:49 AM. All services require a transfer, and take on average 3h 25m. The schedules shown below are for the next available departures.

2h 47m • 1 change

3h 30m • 1 change

4h 19m • 1 change

4h • 1 change

2h 47m • 1 change

3h 30m • 1 change

4h 19m • 1 change

4h • 1 change

2h 47m • 1 change

3h 30m • 1 change

4h 19m • 1 change

4h • 1 change

2h 43m • 1 change

3h 12m • 1 change

4h 22m • 1 change

3h 10m • 1 change

2h 47m • 1 change

3h 30m • 1 change

4h 19m • 1 change

4h • 1 change
Want to know about travelling from Frankfurt am Main to Wertheim? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Frankfurt am Main to Wertheim. However, there are services departing from Frankfurt am Main station and arriving at Wertheim station via Würzburg Main Station station. The journey, including transfers, takes approximately 3h 25m.
Frankfurt am Main to Wertheim bus services, operated by FlixBus, depart from Frankfurt central train station.
Frankfurt am Main to Wertheim bus services, operated by FlixBus, arrive at Wertheim, ZOB station.
Book your Frankfurt am Main to Wertheim bus tickets online with FlixBus and VerkehrsGesellschaft Main-Tauber mbH.
The distance between Frankfurt am Main and Wertheim is 71.1 km. The road distance is 161 km.
You can take a bus from Frankfurt central train station to Wertheim, ZOB via Würzburg, Hauptbahnhof ZOB in around 3h 30m.