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Frederick to San Antonio buses

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Trip Overview

The average bus between Frederick and San Antonio takes 42h 56m and the fastest bus takes 41h 10m. The bus service runs several times per day from Frederick to San Antonio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

42h 56m
Duration
1,750 mi
Distance
$370
Average price
Twice daily
Frequency

Frederick to San Antonio bus times

Buses run twice daily between Frederick and San Antonio. The earliest departure is at 5:05 AM in the morning, and the last departure from Frederick is at 11:40 PM which arrives into San Antonio at 3:50 PM. All services require a transfer at Washington Union Station and take an average of 42h 56m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USAGreyhound USA2d 1h • 3 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA41h 10m • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA44h • 3 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA41h 10m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA44h • 3 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA41h 10m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA44h • 3 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA41h 10m • 3 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA44h • 3 changes
  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAGreyhound USA41h 10m • 3 changes

Frequently asked questions

Want to know about travelling from Frederick to San Antonio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Frederick to San Antonio.ExpandLaunch map view
  • Distance: 1,749.6 mi
  • Duration: 42h 56m

What companies run services between Frederick, MD, USA and San Antonio, TX, USA?

You can take a bus from Frederick Bus Station to San Antonio Bus Station via Washington Union Station, Atlanta Bus Station, and Houston Bus Station in around 36h 25m.

Operators