The average bus between Frederick and San Antonio takes 42h 10m and the fastest bus takes 40h 40m. The bus service runs several times per day from Frederick to San Antonio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Frederick and San Antonio. The earliest departure is at 10:25 AM in the morning, and the last departure from Frederick is at 11:40 PM which arrives into San Antonio at 3:20 PM. All services require a transfer at Washington Union Station and take an average of 42h 10m. The schedules shown below are for the next available departures.
Arrives +2 days



43h • 3 changes
Arrives +2 days



39h 40m • 3 changes
Arrives +2 days



43h • 3 changes
Arrives +2 days



39h 40m • 3 changes
Arrives +2 days



43h • 3 changes
Arrives +2 days



39h 40m • 3 changes
Want to know about travelling from Frederick to San Antonio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Frederick to San Antonio. However, there are services departing from Frederick station and arriving at San Antonio station via Washington Union Station station. The journey, including transfers, takes approximately 42h 10m.
Frederick to San Antonio bus services, operated by Greyhound USA, depart from Frederick Bus Station.
Frederick to San Antonio bus services, operated by Greyhound USA, arrive at San Antonio Bus Station.
Book your Frederick to San Antonio bus tickets online with Greyhound USA and Flixbus USA.
The distance between Frederick and San Antonio is 2,222 km. The road distance is 2,766 km.
You can take a bus from Frederick Bus Station to San Antonio Bus Station via Washington Union Station, Atlanta Bus Station, and Houston Bus Station in around 36h 30m.