The average bus between Frederick and Syracuse takes 15h 43m and the fastest bus takes 13h 45m. The bus service runs several times per day from Frederick to Syracuse. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Frederick and Syracuse. The earliest departure is at 11:30 AM in the morning, and the last departure from Frederick is at 7:30 PM which arrives into Syracuse at 1:35 PM. All services require a transfer at Baltimore Downtown Bus Station and take an average of 15h 43m. The schedules shown below are for the next available departures.
Arrives next day


13h 45m • 2 changes
Arrives next day


18h 5m • 2 changes
Arrives next day


13h 45m • 2 changes
Arrives next day


18h 5m • 2 changes
Arrives next day


13h 45m • 2 changes
Arrives next day


18h 5m • 2 changes
Want to know about travelling from Frederick to Syracuse? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Frederick to Syracuse. However, there are services departing from Frederick station and arriving at Syracuse station via Baltimore Downtown Bus Terminal, Baltimore, MD. The journey, including transfers, takes approximately 15h 43m.
Frederick to Syracuse bus services, operated by BayRunner Shuttle, depart from Frederick Bayrunner Office station.
Frederick to Syracuse bus services, operated by BayRunner Shuttle, arrive at Syracuse Bus Station.
Book your Frederick to Syracuse bus tickets online with BayRunner Shuttle and Flixbus USA.
The distance between Frederick and Syracuse is 417.6 km. The road distance is 752 km.
You can take a bus from Frederick Bayrunner Office to Syracuse Bus Station via Baltimore Downtown Bus Station and Newark Penn Station in around 11h 10m.